This volume of proceedings contains the papers presented at the XXII Brazilian Symposium on Geoinformatics, GEOINFO 2021. The Earth Observation and Geoinformatics Division of the National Institute for Space Research (INPE) and the Cartography Department of the State University of Rio de Janeiro (UERJ) organized this edition. Due to the uncertainties of the COVID-19 pandemic GEOINFO 2021 was again entirely online. But once more, the GEOINFO community attended the Symposium and engajed in exciting virtual discussions. In this year's edition, a program committee reviewed eighty four high-quality submissions and selected nineteen full papers, eleven short papers, and two software demonstrations for oral presentation during the Symposium. One hundred and twenty researchers, students, and professionals from 24 different institutions authored the accepted papers. We express our gratitude to the GEOINFO 2021 Program Committee members, that devoted their time to help us to select the papers presented in this edition. Moreover, this year the GEOINFO community enjoyed three keynote talks: Dr. Baudouin Raoult from the European Centre form Medium-Range Weather Forecast (ECMWF) presented the talk Copernicus Climate Data Store; Dr. Joana Simoes from the Open Geospatial Consortium (OGC) delivered the keynote Geospatial Data On The Web (In The Era Of REST, JSON And OpenAPI) and, finally Prof. Dr. Antonio Tommaselli, from the São Paulo State University (UNESP), presented the talk Photogrammetry Meets Proximal Remote Sensing. So once again, we had an excellent program for the GEOINFO 2021 that could be accessible from the digital platform used to hold the Symposium and broadcast live on YouTube. We appreciate the support from the Sociedad Latinoamericana en Percepcion Remota y Sistemas de Informacion Espacial - Chapter Brasil (SELPER Brazil) that broadcasted GEOINFO 2021 online on its YouTube channel. And the Brazil Data Cube (BDC) project that sponsored the online platform used in the Symposium. We thank Luciana Mamede for her help with these platforms. Finally, we want to thank the GEOINFO community, which showed its resilience in these difficult times of pandemic, as well as its capacity to adapt to the online mode to continue the GEOINFO Symposium series.